Animals who spend the winter in states of suspended animation — hibernation — don’t experience significant muscle and bone wasting. Their existence and ability to reversibly turn off biological processes seemingly necessary for life may well hold the key to creating the conditions required for the human hibernation strategy that could pave our way to surviving long interstellar voyages to distant stars.
In fact, the use of biostasis has already been proposed for the transport of large numbers of travellers to Mars, where crew members will be sustained with specially formulated total nutrition liquids while they “sleep.”
How do we translate hibernation in animals to hibernation in humans? Recent work has uncovered such an ability in animals that are evolutionarily similar to humans: hibernating primates. What is unique about these primates is that they can enter a state of hibernation when resources are scarce and temperatures become cold, and do so without seriously dropping their body temperature.
One of the driving forces behind this extreme ability is microRNAs — short pieces of RNA that act as molecular gene silencers. MicroRNAs can regulate gene expression without altering the genetic code itself. By studying the microRNA strategy these animals use, we can exploit this genetic on/off switch for rapid, reversible changes that could aid hibernation in humans.
Our work on gray mouse lemurs (Microcebus murinus) shows how microRNAs control which biological processes remain on to protect the animal and which ones are switched off to save energy. Some of these microRNAs were found to combat muscle wasting during hibernation. Other roles seem to involve preventing cell death, slowing down or stopping unnecessary cell growth, and switching fuel stores from quickly consumed sugars to slower-burned fats.
While microRNAs are a promising avenue of research, they are just one piece of the puzzle. Our lab is also looking into other aspects of how primates hibernate, such as how these lemurs protect their cells from stress, control global gene levels and how they store enough energy to survive hibernation.